Blood clotting factors may help fight multi-drug resistant superbugs

Published on 08/09/2019 | by Waterline Admin

Coagulation factors, which are involved in blood clotting after injury, may offer new strategies for fighting multidrug-resistant bacteria, according to a study published in Cell Research.

Infections caused by these bacteria pose an urgent public health risk, as effective drugs to combat them are lacking. A deficiency in blood coagulation factors – for example in patients with the blood clotting disorder haemophilia – has been associated with bacterial infection diseases such as sepsis and pneumonia, leading to the suggestion that these coagulation factors may have a role in anti-infection mechanisms as well as bloody clotting. 

Now a group of researchers at Sichuan University, China, has shown that the factors VII, IX, and X – which are well known for their roles in blood coagulation – may act against Gram-negative bacteria, including extensively drug resistant pathogens such as Pseudomonas aeruginosa and Acetinobacter baumannii. Both bacteria were recently listed by the World Health Organisation among 12 bacteria that pose the greatest threat to human health because of their antibiotic resistance. Gram-negative bacteria are characterized by their cell envelopes, which are composed of an inner cell membrane, a thin cell wall and an outer membrane that make them harder to kill.

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Grime Scene

ANNOUNCING OUR NEW GRIME SCENE COMPETITION:

Following on from the successful Grime Scene competition, we have decided to continue the theme for another year, but with a twist. This year, we are asking for photographs of the grimiest pictures you can find accompanied with another photograph of how the ‘scene’ has been improved by your maintenance or cleaning.


We will display the photographs in each of the Waterline editions throughout 2024. The ‘most improved’ picture will be chosen by WMSoc members via an online vote. The winner will receive a £25 Amazon Gift Voucher after the Winter 2024/25 edition has been published.


Please send your photographs to:
waterline@wmsoc.org.uk.


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SolidTek® has launched its NEW Biocide Feeder which is functional, compact, and environmentally-friendly.

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Lovibond MD640 Photometer (PTSA & Fluorescein capable)

Product Spotlight Drop Test Kits

How many times have you heard … ‘we’re not sure what the system volume is’. A common problem which can be expensive - wasting chemical over dosing, or underdosing so the treatment is ineffective (i.e. shock dosing a biocide). The MD640 photometer has PTSA & Fluorescein capability built in. Simply use our System Checkers to add to an unknown system and read a PTSA or Fluorescein levels to accurately identify the system volume.

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