Free access scientific paper: The Life Cycle of L. pneumophila: Cellular Differentiation Is Linked to Virulence and Metabolism

Published on 01/26/2018 | by Waterline Admin

Legionella pneumophila is a gram-negative bacterium that inhabits freshwater ecosystems, where it is present in biofilm or as planktonic form. L. pneumophila is mainly found associated with protozoa, which serve as protection from hostile environments and as replication niche. If inhaled within aerosols, L. pneumophila is also able to infect and replicate in human alveolar macrophages, eventually causing the Legionnaires’ disease. The transition between intracellular and extracellular environments triggers a differentiation program in which metabolic as well as morphogenetic changes occur. We here describe the current knowledge on how the different developmental states of this bacterium are regulated, with a particular emphasis on the stringent response activated during the transition from the replicative phase to the infectious phase and the metabolic features going in hand. We propose that the cellular differentiation of this intracellular pathogen is closely associated to key metabolic changes in the bacterium and the host cell, which together have a crucial role in the regulation of L. pneumophila virulence.

 

READ MORE

Product & Service Spotlight

Introducing B & V Chemicals' new film forming amines for closed circuits and steam boilers.

Product Launch: Film forming amines.

This all-in-one solution offers low-dose, cost-effective treatment. Improves heat transfer efficiency by removing corrosion deposits, leading to cleaner surfaces. Enhances energy and resource efficiency by reducing Total Dissolved Solids (TDS). The stable film provided by polyamines ensures superior corrosion control, promoting longer equipment lifespan.

Plus - environmentally friendly, offering a greener alternative to traditional treatments.

Contact us on ownlabel@bvwater.co.uk for further information.

How the NEW SolidTek® Biocide Feeder Package will BENEFIT YOU

SolidTek® has launched its NEW Biocide Feeder which is functional, compact, and environmentally-friendly.

Designed for use with SolidTek’s® enhanced bromine biocide, BromTek, it offers multiple benefits:

SAFER
Reduced exposure to fumes and bromine dust (non-pressurised system).

EFFECTIVE
Use with field proven mixed hydantoin biocide - better performance than standard bromine tablets.

COMPACT
Wall mounted reducing footprint of installation.

QUICK & EASY
Charge with product in under 5 minutes without isolation from the system.
SUPPORT

Product calculators and tech support available.

Lovibond MD640 Photometer (PTSA & Fluorescein capable)

Product Spotlight Drop Test Kits

How many times have you heard … ‘we’re not sure what the system volume is’. A common problem which can be expensive - wasting chemical over dosing, or underdosing so the treatment is ineffective (i.e. shock dosing a biocide). The MD640 photometer has PTSA & Fluorescein capability built in. Simply use our System Checkers to add to an unknown system and read a PTSA or Fluorescein levels to accurately identify the system volume.

The Hydrosense PRO range

Hydrosense

The Hydrosense PRO range pioneers Legionella pneumophila detection, the cause of over 97% of Legionnaires’ disease outbreaks, by identifying all the serogroups 1-15 of this dangerous Legionella species. This easy-to-use, highly sensitive test uses unique filtration, offering a three-line test result that distinguishes between serogroup 1 and serogroups 2-15 within 25 minutes. The water test has a level of detection of 100 CFU/L and swab tests detect 200 CFU per swabbed area, providing crucial, rapid insights for water safety management.