Murepavadin (POL7080), Polyphor‘s lead investigational antibiotic targeting Gram-negative bacteria, behaved as expected and was well-tolerated when administered to mice harboring a lung infection caused by Pseudomonas aeruginosa, data from a preclinical study show.
Of note, P. aeruginosa is a bacteria that often infects the lungs of patients with cystic fibrosis (CF).