Howard S, de Dios R, Maslova E, Myridakis A, Miller T, McCarthy R. Cell Reports 115650, 2025
Highlights:
- A clinical isolate of Pseudomonas aeruginosa (PA-W23) can degrade a medically relevant plastic (polycaprolactone), by 78% in 7days.
- Encodes a novel polyesterase Pap1, which is responsible for plastic-degrading activity.
- aeruginosa (PA-W23) can use plastic as a carbon source to grow.
- Pap1 can influence virulence phenotypes, such as biofilm formation, in the presence of plastic.
- Given the central role of plastic in healthcare, screening nosocomial bacteria for plastic-de grading capacity should be an important future consideration.
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